Research Progress on Production of Podophyllotoxin from Sinopodophyllum hexandrum

编号 zgly0000335582

文献类型 期刊论文

文献题名 Research Progress on Production of Podophyllotoxin from Sinopodophyllum hexandrum

作者 LiuHaijun  XuYan  SuGuoqing  LiChunyan  WangLi  LiuYujun 

作者单位 CollegeofBiologicalSciencesandBiotechnology  BeijingForestryUniversity  Beijing100083  P.R.China 

母体文献 中国林学: 英文版 

年卷期 2004,6(1)

页码 48-53

年份 2004 

分类号 Q946  R282.71 

关键词 鬼臼毒素  中国鬼臼属  植物  细胞培养  须根 

文摘内容 Podophyllotoxin is isolated mainly from the rhizomes of Podophyllum plants, and serves as the main precursor for synthesis of anticancer drugs, such as VP-16 and VM-26. VP-16 and VM-26 are used for curing lung cancer, testicular cancer,neuroblastoma, hepatoma and other tumors. However, these plants are all near-extinction species due to over-collection and their own biological characteristics. The chemical synthesis of podophyllotoxin is so complicated that its price is unbelievably high.This paper discusses the current status of the biosynthetic pathway of podophyllotoxin and that of the podophyllotoxin production using several biotechnological approaches such as plant organ cultures, plant cell cultures with both flasks and bioreactors, hairy root cultures, bioconversions and metabolic regulations。